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Collins is retiring after 12 years of leading the federal health agency. He parts with a warning about the dangers of yielding to pandemic fatigue. "The virus is not tired of us," he says.

The announcement by the West Virginia Democrat dooms the $2 trillion social spending and climate legislation, which needs support from every Senate Democrat in order to pass through the 50-50 chamber.

Deliberations are set to begin Monday in a trial that will determine whether the disgraced former CEO of the biotech startup Theranos faces possible prison time or walks free.

The highly transmissible variant has again upended life in the U.S., as officials warn of a coming spike in cases and people race to get booster shots and coronavirus tests during the winter holidays.

The rapper was hailed as "the most original West Coast stylist in decades." He was reportedly stabbed at the Once Upon a Time in LA music festival.

COVID-19 surge forces California to slow reopening. U.S. court hearing may decide the fate of more than a million international students. And, South China Sea becomes a dangerous military flashpoint.

We asked for your questions on navigating the holiday blues. Clinical psychologist Andrea Bonior guides us through some rough patches involving family, money, loneliness and safety.

Our picks for best new games run from the humorous to the horrific (sometimes, both at once!), from tight single-player stories to sprawling online sandboxes.

Our poll of NPR staff and contributors produced dozens dozens of favorite games. We've tagged ones that are appropriate for kids, and for those who may be new to the hobby.

In times of crisis, leadership experts recommend a blunt approach. But in the early days of the pandemic, President Trump chose the opposite tactic, downplaying the threat reportedly to reduce panic.